General Cell Lines and Cell Cultures
Genscript Corporation HEK293/EP1 Stable Cell Line
Recombinant HEK293 cells stably overexpress human prostaglandin E receptor 1 (PTGER1) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Eurofins Discoverx PathHunter C2C12 CXCR4 β-Arrestin Cell Line, 2 vials. (93-0203C7)
The PathHunter CXCR4 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. [ligand]) based activation of CXCR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR4 and EA-tagged β-Arrestin-2. Activation of CXCR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Brainxell Inc Spinal Motor Neurons (Human iPSC-Derived, Male Line, 5M)
Human spinal motor neurons derived from iPSC line WC-30, male. Contents: 1 vial of ≥5x10^6 viable cryopreserved cells. Marker Expression: Spinal Motor Neurons (BX-0100) have high neuronal purity (>80%) and consist of greater than 70% motor neurons. Labeling with the pan-neuronal marker MAP2 (green) and the motor neuron-specific marker FOXP1 (red) highlights the purity of this neuronal product. Function: Spinal Motor Neurons exhibit pronounced electrophysiological activity after two weeks in culture, as demonstrated by multi-electrode array (MEA) recordings. Related diseases: Amyotrophic Lateral Sclerosis (ALS), Spinal muscular atrophy (SMA), & Spinal Cord Injury. Primary neurotransmitter released: Acetylcholine
Genscript Corporation CHO-K1/ADRA1D Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 1D (ADRA1D) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/CT/G15 Stable Cell Lin
Recombinant CHO-K1 cells stably overexpress human calcitonin receptor (CT) on the surface and contain high levels of G protein G q and G s to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/cyno BDCA2 Stable Cell
BDCA-2 is a novel type II C-type lectin which shows 50 7% sequence identity at the amino acid level to its putative murine ortholog the murine dendritic cell associated C-type lectin 2 In addition to its antigen capturing function BDCA-2 can mediate potent inhibition of induction of IFN- / expression in PDCs Production of IFN- / in response to several different types of viruses bacteria CpG-DNA dsRNA and SLE serum is by far the most prominent feature of PDCs
American Research Products Inc Human Fc receptor panel 9 x 1MG
A panel of 9 individual proteins consisting of all human Fc gamma receptors, including the allotypic variants, and FcRn. The 9 proteins are CD64, CD32a [167H], CD32a [167R], CD32b, CD16a [176F], CD16a [176V], CD16b [NA1], CD16b [NA2] and FcRn (consisting of FCGRT and B2M). Each protein consists of the extracellular domain fused with a C-terminal tag consisting of the AVI tag, TEV protease recognition sequence and a 10-His tag. All proteins are provided in unconjugated form.
Cayman Chemical Cas9 mRNACap-1mo5U 1mg
An mRNA for the expression of Cas9; encapsulation in LNPs can be used for mRNA delivery and expression of Cas9 in vitro or in vivo
KYINNO BIOTECHNOLOGY (BOSTON) INC HEK293-APP695-SWEDISH CELL LIN
NC3252757 HEK293-APP695-SWEDISH CELL LIN
ACCEGEN BIOTECH Diseased Human Lung Fibroblast, Idiopathic Pulmonary Fibrosis ≥ 0.5 million/ 1 frozen vial
Lung fibroblasts are considered as the key effector cells in Idiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease that commonly seen in elderly with unclear etiology. Characterized by excessive fibroproliferation and extracellular matrix accumulation, IPF is associated with progressive decline in lung function, poor diagnosis, and limited treatment option. Studies have suggested that transforming growth factor (TGF)-β induced alveolar epithelial cells (AEC) can undergo epithelial-mesenchymal transition (EMT) and serve as a source of fibroblast or myofibroblast in fibrosis. Aging is also a main contributor to IPF where senescence fibroblasts show abnormal metabolism and senescence-associated secretory phenotypes.
Lonza Walkersville HPAEC – Human Pulmonary Artery Endothelial Cells
Lonza's Human Pulmonary Artery Endothelial Cells (HPAEC) and media are convenient and easy to use, allowing the researcher to focus on results. Cryopreserved HPAEC cells are shipped in third passage. Proliferating cells are shipped in fourth passage. Cells isolated from Diabetes Type 1 and 2 are also available.Clonetics cells, medium and reagents are quality tested together and guaranteed to give optimum performance as a complete cell system.Benefits:Assured for experimental use up to 15 population doublings All cells test negative for mycoplasma, bacteria, yeast, and fungiHIV-1, Hepatitis B and Hepatitis C are not detected for all donors and/or cell lotsCharacterized by morphological observation throughout serial passageCertificate of Analysis provided for every cell lot Applications:Hypertension Arteriosclerosis InflammationOncologyDrug screening Content:1 x Cryopreserved ampule of HPAEC containing ≥ 500,000 cells
Cell Applications Inc Proliferating Dermal Fibroblasts (HDF), Neonatal
Proliferating Dermal Fibroblasts (HDF), Neonatal
Cell Applications Inc Proliferating Dermal Fibroblasts (HDF), Neonatal
Proliferating Dermal Fibroblasts (HDF), Neonatal
Cell Applications Inc Proliferating Pulmonary Artery Endothelial Cells (HPAEC), Adult
Proliferating Pulmonary Artery Endothelial Cells (HPAEC), Adult